Tea Time学术活动—公派访学报告

报告题目: Dynamics of Context-Dependent Microbial Consortium of Predator and Prey

报 告 人: 毛俊雯 (教授)

时    间：7月2号 (周二) 15：00～16:00

地    点：1-401 物理学科会议室

        Abstract： Syntheticmicrobial consortia are a rapidly growing area of synthetic biology. So far,most consortia are designed without considering their environments; however, innature, microbial interactions are constantly modulated by cellular contexts,which in principle can alter community behaviors dramatically. Here we presentthe construction, validation and characterization of an engineered bacterialpredator-prey consortium that involves a chloramphenicol(CM)-mediated,context-dependent cellular interaction. By conducting the experiments and thesimulations of mathematical models, we show that varying the CM level in theenvironment can induce the ecosystem to success with distinct patterns fromprey dominance to prey-predator crossover and to ecosystem collapse, We alsoillustrate that such a dependence enriches community dynamics under differentinitial conditions and further test the resistance of the consortium toinvasion with engineered bacterial strains. This workexemplifies the role ofthe context-dependence of microbial interactions in moderating ecosystemdynamics, underscoring the importance to include contexts into the design ofengineered ecosystems for synthetic biology applications.

        报告人简介：毛俊雯，博士，教授。1992年获中国科学技术大学学士学位，2006年6月获浙江大学物理学博士学位。1998年起在华体会app官网（中国）集团有限公司任教，主要研究领域：非平衡统计物理问题、基因网络调控的随机动力学。2007年入选浙江省高等学校青年教师资助计划资助，2013年入选浙江省高校中青年学科带头人，2017年获“华体会app官网（中国）集团有限公司第四届陆增镛教师奖”，现担任浙江省“十三五”特色专业负责人，浙江师范大学兼职硕士生导师。2018年3-8月由国家留学基金委资助赴美国伊利诺伊大学香槟分校学术交流。近年来在ACS Synth. Biol.，Biophys. J.，Phys. Rev. E，Europhys. Lett.等国内外刊物上发表SCI论文20多篇，出版学术译著1部，主持国家自然科学基金项目4项，其中在研面上项目1项。